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HyaluronicPERFECTION.com provides a comprehensive resource, delivering the latest information on Hyaluronic acid, a fundamental substance for youth and well-being inside and out.

Hyaluronic acid is recognised by doctors and scientists as not only a fundamental reason for skin ageing and eye sight disorders, but also, a worldwide, phenomenon for the surgical and aesthetic beauty enhancement industry.

HyaluronicPERFECTION.com aims to share information with you that will change your life!

  • Why does our skin become naturally dryer as we get older?
  • Why does a child's skin heal so fast and heal scarlessly?
  • Why do we appear to age faster after 40yrs old and even faster after 60ys old?
  • Why do our joints stiffen and become painful with age?
  • Why do we develop eye disorders as we age?

No matter how amazing we already know a substance is to the human race, it's within our nature to better understand, develop and improve its performance and useful applications.

  • Why do surgeons inject Hyaluronic acid directly into problematic joints and use it to treat osteoarthritis?
  • Why is Hyaluronic acid utilised for eye surgery, to resolve problems such as corneal transplantation, cataract removal, retina repair etc.?
  • Why have dermal fillers (Hyaluronic acid injections) become a worldwide phenomenon for those who wish to turn-back-the-hands-of-time and appear 10 years younger?
  • Why have we manufactured thousands of topical skincare products and oral supplements containing this naturally occurring substance we are born with??
  • Why for over 100 years have scientists researched this molecule, and wrote thousands of research papers, resulting in hundreds of products and millions of investment?

The last 10 years in particular, allow us to benefit from the feedback of thousands of people that have embraced the benefits of Hyaluronic acid. Consumer feedback reinforces the Hyaluronic acid phenomenon:

  • Skin instantly softer, smoother and most importantly 'super' hydrated
  • Appearance of lines and wrinkles decrease or disappear completely
  • Skin heals and repairs faster and more perfectly
  • Hair thickens, hair growth increases and in some cases, original colour is restored
  • Increased sense of well-being and healthier looking
  • Eye area gains re-bloom, eye colour restored, eye disorders correctedd
  • Joints, knees injuries and osteoarthritis disorders improved, arthritic pains reduced

It's a fact that depleted amounts of Hyaluronic acid contributes to all of these ageing symptoms. Hyaluronic injections are vast becoming the standard solution for resolving joint, osteoarthritis, eye sight related disorders, and external beauty enhancement. Topically applied serums and creams are in extreme demand for enhancing visual beauty and protecting against the daily environmental skin aggressors that excel ageing.

Have you ever considered the benefit that could be gained through consuming Hyaluronic acid orally on a daily basis? Hyaluronic acid oral supplement products are not new to the market however; research shows that the lack of awareness, combined with the cost of Hyaluronic acid supplements, has resulted in slower uptake.

Compared to other anti-ageing and health ingredients, Hyaluronic acid is an expensive ingredient for manufacturers of topical skincare and oral supplements to include within their products in high, effective concentrations.

HyaluronicPERFECTION.com is a leading resource and researcher of Hyaluronic based products. We identify, research, test and record evidence that allows us to endorse products for their ability to add value to people's lives. There are many considerations when establishing a products quality, true capability, performance and overall value. Perhaps the main characteristics of a quality product is based on the origin of Hyaluronic acid, the concentration, the weight of the molecules used and its claim, in particular its ability to stimulate, protect and supplement Hyaluronic acid within the skin.

  • Hyaluronic acid – Beginning and End!

    • We have around 15grams of Hyaluronic acid within our bodies
    • More than half is located in skin and remainder; muscles, skeleton, joints, blood and lymph
    • Every day we lose around one third (5 grams) of our total Hyaluronic acid content
    • Fibroblast cells work hard to regenerate those 5 grams of Hyaluronic acid
    • With age the fibroblasts begin to produce (regenerate) less Hyaluronic acid
    • Environmental factors can increase the speed in which Hyaluronic is naturally degraded
    • In the later years it's possible to have ultra-low levels, even zero Hyaluronic acid left

    Hyaluronic Acid – Water Fountain of Youth

    • A child's body is around 80% water, average adult around 55/60% water
    • Water is vital for our survival and fundamental for optimal health
    • Lack of water (moisture) within our skin correlates directly to accelerated skin ageing
    • Our bodies contain billions and billions (trillions) of cells which are surrounded by Collagen
    • Collagen is an important protein, found within bone, cartilage and connective tissue
    • Hyaluronic acid provides vital support by holding moisture, which keeps Collagen hydrated
    • Hyaluronic acid is responsible for ensuring Collagen does not dry out and can be found in and around cells, collagen and connective tissue (the extracellular matrix).




    Conclusion: Hyaluronic acid is the amazing water-binding molecule which we have plenty of in childhood but which depletes with age. By understanding the importance of this molecule and the rate in which it depletes (synthesises), decreases more rapidly with age, allows us to take measures to protect and maintain this important anti-ageing molecule.

  • Hyaluronic Acid is a component of our body from birth, but the production of this fundamental molecule decreases as we get older, which can result in both physical the visual ageing. If we could maintain the production and protect Hyaluronic Acid within our body, we would age slower.

    Hyaluronic Acid (HA) is naturally broken down by enzymes within our bodies called Hyaluronidase. These Hyaluronidase enzymes are important to control HA levels but are also responsible for the destruction of Hyaluronic acid when the body may no longer be able to produce HA. The rate, in which Hyaluronidase enzymes are able to breakdown HA, can be increased and triggered by factors such as UV sunlight, viruses and excess minerals.

    Aside from eating a good balanced diet we can try to counter the effects that our environment has on our bodies. One of the most well-known reasons for skin ageing is exposure to UV sunlight. Sunlight can induce excess free radicals (oxidants) within our skin, which can trigger Hyaluronidase enzymes to attack and degrade the Hyaluronic acid content. Many sunscreens on today's market now advertise anti-oxidants which help to diffuse the hazardous capability of excess free radicals. Keep alert for products that have an ANTI-Hyaluronidase activity which contain ingredients that can fight the enzymes that destroy our HA content.

  • Hyaluronic acid (HA) is produced by fibroblast cells within our body. As we get older the amount of HA we produce is less than the amount we lose daily. The average person loses between 3 to 5 grams of HA per day, but this varies depending upon age and other factors such as UV sunlight, viruses and certain excess minerals. It is said that older fibroblast cells produce less Hyaluronic acid than younger cells which explains why, with age, we are not producing enough HA to maintain our 15grams.

    One approach to this problem is to stimulate the fibroblast cells to produce more Hyaluronic acid. There are a number of substances (ingredients) that have shown ability to stimulate fibroblasts which in turn make the fibroblast more productive. Fibroblast cells within our skin our located within the dermis (dermal) skin layer, which is located several skin layers deeper than the skin surface. It's important to understand this because many topical skincare products that claim they stimulate fibroblast activity are mostly flawed, because most products on the market are not capable of penetrating through those several (epidermis) skin layers. Also consider that skincare products capable of penetrating the dermal skin layer are normally classed as pharmaceuticals and have special delivery systems that take ingredients to the lower skin layers. The risk with any skincare product that is transporting ingredients to the dermal layers is the ingredients could reach the bloodstream, so consider the products ingredients on this merit also. The proof is to make the test, is the skincare product helping you to stay young and most importantly does it keep your skin really well hydrated.

    Oral supplements providing ingredients that have been deemed safe for oral consumption could be another way to reach and stimulate fibroblast activity. Aesthetic beauty enhancement treatments including glycolic peels and laser treatments often claim they stimulate fibroblast activity.

  • There is no test that can analyse how much Hyaluronic acid you have within your body. A blood test can show how much you have within your bloodstream but it's unlikely to be much, unless you have excess amounts which are being excreted through your blood steam. What we do know is there are thousands of people that have used products containing Hyaluronic acid for many years, and the reviews and reports are simply astounding.

    In addition to protecting our HA content and utilising methods to produce more HA naturally, it's also worth considering reinforcing the hyaluronic acid content daily with oral supplements and/or topical skincare products. All good quality skincare products that contain Hyaluronic acid will at minimum provide excellent hydration benefits to the skin. There are many reports and certainly claims that skincare products reduce lines and wrinkles but this doesn't happen overnight. Perhaps the most in demand method on today's market for radical over-night change is done through injecting Hyaluronic acid directly into ageing skin. The injections are known as wrinkle filler injections or dermal filler injections and they use cross-linked Hyaluronic acid, which can last for 6-to-18months depending upon the injection manufacturer. Interestingly, even though the Hyaluronic acid is cross-linked, it will over time be broken down by our Hyaluronidase enzymes in the same way our own HA is broken down.

    Whether you are supplementing HA topical, orally or surgically the big fat benefit of the Hyaluronic acid anti-ageing molecule is its ability to hold moisture and keep skin plumped and hydrated. More recently we are now witnessing dry eye and other disorders of the eye not only being treated surgical but also daily, through the use of eye drops containing Hyaluronic acid.

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Potent 29% hi-tech active formula, fast acting, unique anti-ageing results for peri-orbital fragile zones.

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Dual action hyaluronic acid and antioxidant eye contour fluid containing, Tetrapeptide-3 and 8, Hyaluronic Acid, Glycosaminoglycan's.

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Dr. Hafeesa Sameem - Hyaluronic Acid Biopsy!

Hyaluronic Acid for Age Reversal and Maintaining Health

Beauty may lie in the eye of the beholder. People can scream themselves hoarse asking people to only look at inner beauty. But the fact remains that first impressions are made based on first look. Your dressing, grooming etc. plays an important role on making that coveted good first impression. But if there is one single most important feature that seals the fate of the first impression, then that would of course be the skin! Healthy looking supple skin often takes you places and no one can deny that. This is the simple reason behind the exponential skincare and beauty market boom. Every woman dreams of fantastic skin and every company in the industry constantly tries to redefine "fantastic skin"! But this a tall order and one that many go to extreme lengths to fulfil. In the quest for perfect skin, one would have heard of extreme measures like drinking snakes blood in Thailand or a wonder cream from Bali. Though Thailand and Bali are wonderful tourist destinations, one really doesn't have to travel to end of the world for this dream!

You may believe in the Big bang theory or be a very religious person in your chosen religious belief. But whatever your take on this is, you have to admit that the human body is the best innovation ever. It is obvious that whoever or whatever created the human race, seems to have thought of everything! Long story short….you want good skin? The answer does not lie in India or China…it lies within you. Yes we are talking about Hyaluronic acid which has taken the dermatological world by storm since its discovery! And it is a simple, humble component found in our own body! So what is it? How can it be used? What can it be used for? Before one gets all excited and starts looking for ways and means to get their hands on this miracle, it is important to get the answers for these questions. It is a big bad world out there, and anyone out to make a quick buck may sell you anything you choose to blindly believe in! So do yourself a favour and gather all the facts and always make informed decisions. We can't make decisions for you but we would certainly like to give you the facts from a medical point of view.

Elixir of Eternal Youth! Yuzuri Hara, Japan!

Anyone who knows anything about hyaluronic acid knows that it is a naturally occurring substance in human beings. But what some may not know would be that they are also found in food sources! Apparently if you had started early enough, you can eat your way to eternal youth! A news story featured on ABC News in November 2000 brought to light an entire village that seemed to have found the elixir of eternal youth! Yuzuri Hara is a small village about a two hour drive away from Tokyo. The villagers were living proof that it is possible to live long healthy lives with beautiful, supple skin to boast! How cool is that? Naturally this garnered a lot of attention and everybody wanted to know the secret! The local doctors believed that this sensational phenomenon can be contributed to their food habits which mainly consisted of potatoes, sweet potatoes and a special dish made from a combination of root vegetables known as konyako. These starches apparently improve the natural regeneration of hyaluronic acid in the body. So if you can't shell out the money for hyaluronic supplements then you could consider surviving on potatoes for the rest of your life! And also bear in mind that these Japanese villagers don't normally consider burgers, pizza and pasta as food choices! Now you have to decide if you can give up everything else and focus only on potatoes.

But this is not a practical option and we are compelled to find a variety of foods that are a good source of hyaluronic acid and hope they work their magic in any small way possible!

What is Hyaluronic Acid?

This should be your first question before you give in to the temptation to know exactly what it can do for you! Hyaluronic acid is also known by names like hyaluronan or hyluronate or simply HA. It has a negative charge and is a non- sulphated carbohydrate or rather glycosaminoglycan. It is found in most living organisms and in humans is found in higher concentrations in the connective tissues in the joints, around the eyes and epithelial layer in the skin. The basic structure of this component would be the simple sugars D-glucoronic acid and D-acetyleglucosamine held together by glycosidic bonds. It is a stable component because of its structural bulk that comes from the basic structural sugars and their bonds with each other. Which is why it is able to maintain the structure of the eyeball for example. Hyaluronan's most significant contribution would be towards cell proliferation and migration. The person who has the claim to being the first to determine the presence and properties of hyaluronic acid would be Endre Balazs in 1942. He discovered it by accident really when he applied for a patent to use it as a substitute to egg white because of its similar consistency. Hyaluronic acid has come a long way since then but it started thanks to this man. He did go on to become an expert on hyaluronic acid and discovered many of the benefits of hyaluronic acid. So kudos to him! It was believed that bakers had smooth hands from working with hyaluronic acid!

In our body, an average person would have about 15 grams of hyaluronan and about a third of this is lost and regenerated every day. But this regeneration process slows down as one loses the battle against aging. But even when fighting a losing battle one does not have to go down without a fight. And there has not been a more resilient species than the human species. That is why years of research has resulted in coming up with hyaluronic acid based products which can help give our bodies natural reserve a boost.

Before you start imagining that some poor souls in third world countries are being forced to sell their hyaluronic acid for this, rest assured that there are other sources of this miracle substance! Hyaluronan can be synthesized by any vertebrate that has membrane proteins known as hyaluronan syntheses types HAS1, HAS2 and HAS3. So hyaluronic acid can be obtained from a number of vertebrates with these proteins. So far, roosters have been a favourite source. But it has been found through research it can also be obtained from bacterial sources so instead of killing roosters and gaining the wrath of animal activists, Bacillus subtilis, a form of bacteria can be genetically modified to give sufficient hyaluronan that is compatible for use in humans.

Hyaluronic acid also has a high affinity for binding with water, thus giving rise to a highly aqueous, jelly like consistency. It is this property that gives it an important role within connective joints, as it provides a cushioning effect to take the abuse of day to day movements! Research has found that besides the affinity for binding substrates, the main deciding factor on the functions would be the molecular weight. The more heavy weight molecules are found maintaining structural integrity and in the joints to provide cushioning effects. The smaller (lower) weight molecules also have an important role to play in wound healing. So the bottom line is that even though the skin care industry has given star status to this wonder substance, it already had humble beginnings in among the medical fraternity. Now that a quick look has been taken at the anatomy, physiology and biochemistry of hyaluronic acid, it is time to take a detailed look at the various uses and benefits.

Food and Natural Sources of Hyaluronic Acid

As already seen, there are plenty of animal sources of hyaluronic acid. Meat eaters probably enjoy better skin as compared to vegetarians. Chicken stew and soup don't only warm your soul, they can give you all the benefits of hyaluronic acid as well. No wonder the Chinese are famous for their chicken soup that they take when healing from any illness or injuries. The hyaluronic acid will help boost immunity and wound healing. Animal source liver is also an exotic way to boost your hyaluronic acid level! Actually this is probably the one case where physicians have to agree that red meats does have its share of benefits but it would be foolish to load up on red meat excessively!

I have yet to come across someone who hates potatoes so throw in the mashed potato into your diet once in a while! And we suggested mashed potatoes, not greasy fried chips! The whole point is to be health conscious so this not an excuse to load up on McDonald's fries! Sweet potatoes are also a simple to consume food. All you have to do is steam or boil and eat! And did we tell you they are good sources of magnesium as well.

For the fruit and vegetable lovers, it is sad but unfortunately these are just not good sources of hyaluronic acid per se. But that doesn't mean there is no hope for you. In fact fruits and vegetables that are high in Vitamin C and magnesium help to boost the body's natural production of hyaluronic acid. In fact they are essential substances for the production of hyaluronic acid. This could be a reason why a western diet that is lacking in fruits and vegetables is not hyaluronic acid friendly. If you have noticed, the Asians seem to be having better skin than their western counterparts. You don't really have to go to Japan to see this! This could largely be attributed to their diets. It is time to become good friends with fruits like bananas, oranges, strawberries, guavas, mangoes etc. Bananas happen to be an excellent source of magnesium. Vegetable like cauliflower, broccoli, asparagus, green beans and Brussels sprouts are also rich in magnesium. Zinc rich foods like peanuts, pumpkins and brown rice are also effective in boosting hyaluronic acid production.

So the next time you reach for the cracker, remember the world of goodness of hyaluronic acid and reach for a banana instead. Your body will thank you for it!

Another important substance which raises the body's hyaluronic acid would be oestrogen, which is probably why women have better skin than men! Soya is great way to raise the oestrogen levels in the body which in turn will help raise the levels of hyaluronic acid. If you are vegetarian, then this could be your best bet next to potatoes! Soya products are known to have a substance known as isoflavanes which are responsible for raising the oestrogen level and hence the hyaluronic acid level. Soya or tofu are also extremely palatable and easy to prepare and again this is a staple in Asian diets. Maybe you can find recipe some interesting recipes on how to prepare soya!

According the United States Department of Agriculture, the red, green, yellow pepper, cilantro and parsley are also good sources of Vitamin C so go ahead make your food more flavourful and colourful!

It is important to be practical and understand that the benefits of taking hyaluronic acid as a food source, is not going to give instantaneous results. So take it slow and slowly incorporate the above mentioned food into your diet. If you go even for a whole week just eating potatoes and nothing else, you are going to feel horrible! So take it slow!

Uses & Benefits of Hyaluronic Acid

Hyaluronic acid is a naturally occurring substance in all cartilage tissues and has more than one important function. A lot of research is still being carried out to fully understand this substance and how it can be optimised to treat or supplement existing treatment modalities. The biggest fan of hyaluronic acid in recent years may be the skincare industry but doctors have been interested in this way before that. It has always been regarded as a substance with huge potential in a wide variety of conditions.

1. For osteoarthritis of joints
Hyaluronic acid is found in abundant amounts in joint cartilages and synovial fluid. Osteoarthritis is an inflammatory condition of joints as a result of the normal wear of tear of daily movement. Hyaluronic acid has been found to play a principle role lubricating the joint and when the lubrication decreases resulting in pain, it is only natural to consider topping it up in the joint. This way lubrication can be maintained keeping the joint resilient to wear and tear so that mobility and flexibility are not compromised. A study published in Current Rheumatology Reports in 2000 found that hyaluronic acid is protective against cartilage breakdown in patients suffering from osteoarthritis. According to many doctors hyaluronic acid injections really does help osteoarthritic patients lead a better life!

2. To maintain integrity of connective tissue like tendons and ligaments.
Our body may be made of bones, organs and flesh but there has to be something that attaches and holds everything together. The heroes who do that would be the connective tissues. Sometimes they even do more than just binding two structures together. They also provide support, protection and even insulation. Tendons are cord-like structures that attach muscle to bone while ligaments help connect two bones with each other. Hyaluronic acid along with collagen and elastin are the basic units of these connective tissues. Hyaluronic acid with its amazing ability to form high molecular weight structures helps give the connective tissue the strength to withstand the pressure of weight and tension of movement.

3. For healthy scalp and hair
If good skin is the ultimate dream of every woman, a healthy radiant mane is a hot second favourite dream. The scalp is structurally similar to skin elsewhere in the body and hair is just a derivative of the skin. The dermal layer in the scalp contains connective tissue which contains hyaluronan as well. Hyaluronic acid with its ability to absorb water weaves its magic by forming the gelatinous fluid which supports, nourishes and hydrates the scalp. A well- moisturized scalp and lustrous hair are all possible due to the presence of hyaluronic acid. So HA is an important component being exploited by companies involved in developing hair care products.

4. For healthy supple lips
Women like Angelina Jolie have worked hard to perfect the pout. Women around the world have tried to emulate the infamous pout. But the pout can be a big turnoff if the skin is dry and chapped! The lips also have a dermal layer with the basic components being hyaluronic acid and collagen. They both jointly work towards maintaining the shape and suppleness of the lips. The collagen is supposed to keep the skin over the lip taut while hyaluronic acid binds with water and forms the magical gelatinous fluid hydrates the rest of the lip tissues, keeping it hydrated and supple so that you can allow that pout to speak volumes about your confidence.

Uses & Benefits of Hyaluronic Acid: Continued

5. For healthy eyes!
After the joints, the eyes are the favourite hangout of hyaluronic acid in the human body. The centre of the eye is filled an aqueous solution made primarily of hyaluronic acid. This is known as the vitreous humor which provides buoyancy to the eyes and plays the important role of shock absorber. It also is the transport source of nutrients for the eyes. Ophthalmologists often inject hyaluronic acid directly into the eye during eye surgery so that the structural integrity is maintained throughout the surgery. Just like in the joint and skin, regeneration of hyaluronic with production of new hyaluronic acid slows down as we age, resulting in some of the common eye disorders.

6. For healthy gums
As soon as someone mentions connective tissues, the mind conjures up an image of a joint. Yes, connective tissues do contribute significantly to maintaining the integrity of joints like the complex knee joint. But many don't know that the gums are also a place where connective tissue can be found! Dense fibrous ligaments help anchor the teeth to the jaw bone. So once again one has to thank hyaluronic acid for maintaining hydration, nourishment and strength to our teeth. It is thanks to hyaluronic acid that our teeth don't chip off when we bite into something hard!

7. And finally for healthy, younger looking skin.
The skin is where the maximum concentration of hyaluronic acid can be found. This is not surprising as the skin is after all the largest organ in the body. About 50% of the total body's hyaluronan concentration can be found in the skin. The skin is actually made up of multiple layers and hyaluronic acid is found in the top most epidermis layer as well the deeper dermal layer. It goes without saying that hyaluronic acid together with collagen play an important role in hydrating, nourishing and maintaining the structural integrity of the skin layers. Hyaluronic acid continuously hydrates the skin by binding up to 1000 times its weight with water. The collagen provides the firmness and elasticity to skin. In facts it is the hyaluronic acid which constantly supplies moisture and nutrition to collagen so that it can maintain its moistness and elasticity. Young skin which has a high concentration of hyaluronic acid will obviously be smooth and elastic. But unfortunately as one ages, the concentration of hyaluronic acid and the ability of the body to replenish HA decreases. Because of this we are forced to say goodbye to well hydrated and nourished skin. Most people watch helplessly as with age, the skin starts drying up and wrinkle after wrinkle appear!

8. For wound healing
Hyaluronic acid has been hailed as a powerful antioxidant thus effortlessly doing its role preventing damage to wounded, inflamed tissues. Free radicals better watch out as hyaluronic is no exotic power berry that one has to burn a hole in the wallet to obtain! It's just another simple yet effective natural protector of the body against injuries and wounds!

9. For strengthening the immune system:
Our immune system is our shield against the forces of nature and everything else in between. If our immune system is weak then even a simple flu bug can show us the way to the graveyard. But as always the body is well-equipped to fight against all odds and hyaluronic acid extends a helping hand in this process as well. It does this by keeping the integrity of tissue structures intact and protected against invasion by viruses and bacteria. Due to its extensive presence in the extracellular matrix, it also plays an important role aiding cellular communication and regulation.

10. For smooth circulation
Hyaluronic acid also plays a role in the circulatory system of the body. Thanks to its lubricating properties, it keeps the flow steady.

Side Effects of Hyaluronic Acid

Ever since hyaluronic acid was thrown into the limelight, it has caught the fancy of numerous curious minds. Hours of sweat and tears have been spent over the years researching this potent substance. Researchers and scientists have come a long way but there is still a long way to go. In this world everything normally happens in a balance. If something has a long list of benefits, then there would always be some side effects as well. When using any product it is not only important to consider the benefits but also to have the knowledge of the negative aspects. Knowledge is power hence by being aware, one can take the necessary precautions.

1. Allergic reactions
These are rare in the case if hyaluronic acid. But the reported cases were usually from those who used products obtained from the rooster. There could be an inherent aversion to animal products by some individuals. But the more recent products that have steered clear from the animal sources are generally safer. Trying any new product is like getting a new car. Always do a test drive first!

2. Pain, swelling and redness
This might occur when hyaluronic injections are given directly into joint spaces in patients suffering from osteoarthritis. The pain, redness and swelling will be at the site of injection and this is usually because of an acute inflammatory reaction. This occurs as a result of tissue damage by the injection itself and the introduction of a foreign substance. The body's natural defence kicks in without realising that is no enemy! This is a common side effect in many patients receiving injectable hyaluronic acids. But this is a short term effect and gets better quite quickly. But you have to see a doctor and take the prescribed anti-inflammatory treatment.

According to study by Narins et al 2003, lip augmentations are the most common source of pain, swelling or bruising following a hyaluronic acid injection. There is also a danger of herpes labia but clinicians avoid this by using prednisolone and or antiviral agents. So want the perfect pout? Go to a reputed clinician who knows what he is doing!

3. Injection site ulcers
Not a common occurrence but has been reported and is believed to be due to arterial occlusion. This is common when injected in the glabellar are. Thankfully sufficient research has been done and there is a protocol in place to look for and treat this if it should occur. Late infections following hyaluronic acid injections are rare and the only two reported cases were two women who had gone to an unlicensed practitioner! (Toy and Frank 2003).

4. Effects due to interactions with other substances
It has been generally observed that some medications taken along with hyaluronic acid don't take too kindly to being taken together. It does seem like vitamin E supplements, aspirin and some NSAIDs don't really get along with hyaluronic acid and ends up causing increased bleeding and bruising. A good clinician should tell you to stop taking these supplements and medications for at least a week prior to getting the hyaluronic acid shot!

5. Side effects of oral hyaluronic acid
Research is still going about how safe is hyaluronic acid orally. It is not advisable for cancer patients with lymphedema to take hyaluronic acid orally. Similarly patients suffering from Rheumatoid arthritis are also advised to steer clear of oral hyaluronic acid and it has been observed to aggravate existing signs and symptoms.

6. Side effects of topical hyaluronic acid
Hyaluronic acid is also available for topical use and so far thankfully no major side effects have been noted with topical use. The known side effect of topical usage would be some minor itching and rashes. But these usually subside within a couple of days. Oral and topical hyaluronic acid are generally considered unsafe in pregnant and lactating women. Some doctors say that injections are safe in pregnant women but not in women who are breastfeeding. But most clinicians do not experiment with hyaluronic acid in pregnant nor lactating women!

7. Serious side effects
Hyaluronic acid is generally safe but serious side effects like difficulty in breathing, hives and ulceration with scarring can happen in patients who are extremely hypersensitive to them. We don't mean to scare you by being morbid but take it as our social responsibility to create awareness. We can't stress enough how important it is to see certified practitioners and follow their advices accordingly. And always, always test drive! And if you are going through a special period in your life like pregnancy and breast feeding, postpone the treatment until your body is back to normal. Always weigh benefits and potential side effects and choose the lesser evil! Talk to your doctor about any concerns or questions that you have. A great way to identify a good clinician would be based on how honest and careful he is in explaining and carrying out the whole process. One can't be too careful…it is your health we are talking about after all!

Hyaluronic Acid Supplements (Injection, Topical, Oral)

So now you know that Hyaluronic acid is a substance that has multiple benefits and the best part of it is that it is made by our body itself! Our body may be constant source of amazement as we keep finding out more and more about all that our body is equipped with. But everything and especially good things come with expiry dates. Given the dynamic nature of our body, one shouldn't be too surprised that our body is undergoing millions of generating and regenerating processes every second of life. The production and breakdown of Hyaluronic acid in our body is not immune to this dynamics. Hyaluronic acid has a relatively short half-life of 1-3 days and hence needs to be replenished every three days, which our body normally does easily. But it is also known that with time, our body gets fatigued and becomes less and efficient. The only way to keep the momentum going would be by supplementing the body with external sources of hyaluronic acid.

Hyaluronic acid supplements have become the latest fad to join the race against time to preserve the beauty and functioning of the human body. The benefits may be numerous but that also means there is a real danger of not using the product correctly as intended. It is also easy to understand how people can be easily misled into believing that this is a miracle elixir and go overboard with the use. It is important to understand the facts and not be carried away with the sales pitches of marketing experts. Always check with a medical practitioner whenever possible. Even otherwise use test doses to make sure you can tolerate the product which you have finally zeroed in on. Here is a quick rundown on the different types of hyaluronic supplements available in the market.

Hyaluronic acid is available for oral intake or for topical use. A qualified medical practitioner will be able to advise you on the form that would best suit your needs. But the general rule of thumb is that oral supplements will help in ailments like osteoarthritis by supplementing the lubricating, cushioning effect of synovial fluid in joints. They are also sometimes prescribed by physicians to aid the healing of fractures, hernias and glaucoma as they supplement naturally occurring hyaluronic acid produced in the body and speed up healing. They are believed to aid the body in the rebuilding of connective tissues that are important for structural integrity. Oral hyaluronic acid helps improve the connective tissues that are integral for the structural integrity of the all too important skin. They also help to hold onto to moisture that leaves skin looking younger and supple.

Topical forms of hyaluronic acid have been known to be used medically for external wound healing due to its' anti-inflammatory properties. But the most well-known topical superstars would be those that are available as injectable or what are popularly known as wrinkle or dermal fillers. These are topical Hyaluronic acid supplements that are available in the form of gels and which are non-toxic and compatible to the form naturally found in our skin. The recent varieties are bio-degradable, stable and do not provoke immunologic reactions. It goes without saying that it is not advisable to self-inject these fillers. It is always safer to approach trained professionals! They are trained for a reason and more than their monetary gains, they are responsible for your safety. At least they will know what to do if you develop any allergic reactions and make sure you are not permanently harmed. And that by itself is worth every penny you are shelling out!

Hyaluronic acid supplements have also found their way into day to day skincare routines and are a part of face washes and moisturisers. However this may not be the best way to make use of hyaluronic acid as we can't ascertain how much of it gets absorbed and whether they can increase the quantity of hyaluronic acid in the body. There is often some confusion regarding this as people are sometimes led to believe that these act in the same as wrinkle filler injections. Although topically applied products may have a daily impact on skin hydration and the appearance of lines and wrinkles, the result is not as effective as injection treatment. Just because a skincare product promotes hyaluronic acid, it doesn't mean to say it will deliver the benefits associated with topical application of HA, mainly due to the lack of hyaluronic acid contained within the product. Looking for products that have invested money into clinical trial evidence is often the easiest way to feel more comfortable of its real capabilities.

There is a lot of research going on in this field and scientist are constantly striving to come up with a superior product that has as little side effects as possible. All said and done, it is important to remember that each and every body is unique and how it reacts to any product cannot be assumed. So make sure you do your homework and find products that suit your body and which your body can tolerate! The supplements are easily available online and in speciality stores. It is important to know that hyaluronic acid supplements are not regulated by the US Food and Drug Administration (FDA). This essentially means that the all the responsibility is on you! Beauty is a quintessential part of life, but with that comes the responsibility of not taking unnecessary risks and losing what is already there! Knowledge is power so make informed choices and always seek professional help whenever possible. The smart way of doing things may be inconvenient but could make all the difference in the world!

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Hyaluronic Acid Skincare Product Guide

HyaluronicPERFECTION.com is a growing resource of information, focusing on the amazing anti-ageing molecule Hyaluronic acid (HA). There are thousands of products containing Hyaluronic acid, which can be topically applied to our skin each day. From one manufacturer to the next, it's almost impossible for the consumer to evaluate the best product to purchase. Most skincare products containing HA as the active ingredient, tend to focus on the benefits HA which include skin; hydration, plumping, smoothing, softening, firming and the reduction of lines and wrinkles.

The big questions remain, "which product provides the best results and which product is the best value?"

The old saying of "what works for one person may not work for another" will always remain a variable when selecting products that will work for you. Using the feedback we receive from users of this site and our understanding of the Hyaluronic acid market place, we have listed questions and answers to help you understand the complexities and considerations within this evaluation process:

What claims does the product make?

There are so many miss-marketed products in the world, however products that originate from Europe and America are regulated in what claims they can make. The first piece of advice is to review the claims made on the product and outer packaging, rather than the content provided on the externally supplied leaflet or website description. Informative, supporting documentation and website descriptions are a bonus, but they are not regulated and can be misleading.

The normal benefits associated with HA active skincare products include skin: hydration, plumping, smoothing, softening, firming, healing, repair, anti-oxidants, free radical scavenger and the reduction of lines and wrinkles. If there are any claims made in addition to these points, it's likely to relate to benefits from other ingredients within the formula. Ask yourself "what are the main benefits you would like to gain?" and identify products that can substantiate their claim with evidence. Try to understand the value of the other active ingredients, and how the combination of ingredients working together in synergy, could help you achieve your expectations.

How many active ingredients does the product contain?

There's a big difference between active ingredients and inactive ingredients. Always look for the active ingredient list first and try to relate these ingredients to the claims and promises made by the product. Products containing loads of ingredients are not necessarily better than products with fewer ingredients, which in fact are often less effective. Skincare products are normally made up of around 70% water or more, because with the addition of 30% ingredients the formula begins to thicken. Skincare products must have preservatives to keep the product from spoiling, do however check the preservatives used because many come with bad publicity including parabens more recently. Products with fewer ingredients are likely to have fewer benefits and claims, for example a Hyaluronic Acid Serum containing several ingredients and the only active is Hyaluronic Acid. With this example you know exactly what the product is capable of doing. The next thing you can explore is how much Hyaluronic acid the product contains. If possible sample the products texture and consistency, monitor how it feels on application to the skin and how the skin feels five minutes after application.

How much Hyaluronic acid is within the formula?

Most of us are familiar with taking an oral multi-vitamin supplements which contains perhaps 30 plus vitamins and dietary minerals. This extremely regulated market is very different to the approach of the 'secret formula' skincare product manufacturers. On the outside of a multi-vitamin container you will notice an exact amount of each vitamin and mineral contained. Generally manufacturers of skincare only tell you the percentages of ingredients within the products for the following reasons:

  • The product contains the maximum concentration of the ingredient and therefore it's impossible for a competitor to promote a more attractive concentration to the consumer.
  • Even they share the percentage of the ingredient used, it may still be masked by other factors such as the size of the particles used or the origin and type of ingredient.

The skincare market has never been so competitive. Market trends suggest consumers will purchase higher priced skincare products providing the claims are backed with real evidence, or they will purchase quality branded products on offer at discounted prices. Obviously there are skincare products available at the lower end of the market however it's unlikely you will find quality, proven ingredients in high enough concentrations, which could be compared to mid-to-higher end products.

Compared to other anti-ageing and health ingredients, Hyaluronic acid is an expensive ingredient for manufacturers of topical skincare to include within their products in high, effective concentrations. From our research there are few effective products containing Hyaluronic acid under £15 retail and these products are questionable when compared to a more concentrated products retailing for £30 plus.

There are claims made by products in today's skincare market suggesting that as much as 15% of the formula is made up of (smaller, lighter weight) Low Molecular Weight (Lmw) Hyaluronic Acid. There are claims that other products containing (larger, heavier weight) High Molecular Weight (Hmw) Hyaluronic Acid of 1% perhaps the most amount of this thick substance you could mix within a formula before it becomes unusable to apply to the skin. There are new breeds of products that contain a mixture of different molecular sizes of Hyaluronic acid but the overall percentages used are not provided.

The amount of Hyaluronic acid within the formula is important but in most cases you will never know the exact amount used. If the product is formulated with few ingredients and heavily focused on the benefits of HA, then you can get a strong indication by the texture of the fluid as you apply to your skin. One of the biggest differences (other than results) we understand between a cheap HA product and a higher end HA product is how it feels when applied to the skin. Many cheap products containing a reasonable concentration of Hyaluronic acid are noted to leave the skin feeling sticky and uncomfortable.

What is the origin of Hyaluronic acid?

Skincare manufacturers may explain whether the origin of the Hyaluronic acid originates from an animal source or a non-animal source. So far, roosters have been a favourite source. But it has been found through research it can also be obtained from bacterial sources so instead of killing roosters and gaining the wrath of animal activists, Bacillus subtilis, a form of bacteria can be genetically modified to give sufficient hyaluronan that is compatible for use in humans. I don't believe there is any difference in the capability of the HA but it can be an important personal consideration.

What is the molecular weight of the Hyaluronic acid used?

Hyaluronic Acid is categorised into three sizes/weights:

  • (Lmw) Low Molecular Weight (smaller and lighter)
  • (Mmw) Medium Molecular Weight (mid-sizes and mid-weight)
  • (Hmw) High Molecular Weight (larger and heavier)

The size of a Hyaluronic acid molecule is measured in Daltons. Lmw is between 50,000 Daltons and 1 million Daltons, Mmw 1-to-2 million Daltons and Hmw over 2million, commonly found at 4million Daltons. In addition there's Super Low Molecular Weight (SLMW) hyaluronic acid which is measured for molecules smaller than 50,000 Daltons.

There are a few things to consider with regards to the molecular weight of Hyaluronic acid found within skincare products:

  • Lower molecular weight (Lmw) Hyaluronic acid (HA) will penetrate further into the skin than higher (heavier, larger) weight molecules. This is the reason why many skincare products containing Hmw Hyaluronic acid were subjected to bad publicity for not penetrating deep enough into the skin to gain the acclaimed benefits. If you find your HA skincare product is sitting on the skins surface layer and perhaps the gel is rubbing off your skin hours later, it's possible its either not penetrating or you are applying way to much.
  • Lmw HA will penetrate through the skin layers more easily than Hmw and in theory give better results on this basis. This said, Lmw is smaller in size and will be destroyed faster by your body's natural Hyaluronidase enzymes. In addition, Lmw is lighter than Hmw, and therefore will hold and bind less water so the moisturising, hydration factor is deemed less effective.

The quest for topically applied skincare manufacturers has been to find ways to transport higher weight Hyaluronic acid molecules (Mmw and Hmw) through to the deeper skin layers where it would be most effective. There are two methods used on the topically applied skincare market today. The first is the use of a delivery system which may use Nano particles (carrier capsules which are can penetrate the deeper skin layers) to transport the other ingredients through the skin. There is a lot of research about this methods safety, one study on the use of Nano capsules within marine life proved quite concerning. Another way is the use of specialist skincare ingredients that are capable of skin penetration and carrying other ingredients like Sodium Lactate used within Innoderms, Bio Logica products.

It's all about being aware of the factors that differentiate one Hyaluronic acid product from another. Just because a product doesn't penetrate the dermis skin layers doesn't mean the product is useless. There are several skin layers above the dermis known as the Epidermis and there is 4 to 8 times more HA in epidermis than in dermis.

How is the product administered?

Specifically focusing on topically applied skincare products you will find HA in the form of creams, fluids (lotions) and serums. Creams are thicker in texture and less fluidly than serums/oils and will naturally not absorb and penetrate through the skin as well. This said most reputable manufacturers producing products on today's market will have some sort of delivery mechanism to enhance the penetration. Perhaps the type of product you choose is really down to personal preference but the general recommendation is for serum based product.

What evidence or clinical studies are associated with the product?

There are many products at the lower priced end of the market that would not have gone to the expense of clinical trials to prove the acclaimed results of their products. At the lower end it can be just as effective to rely on customer testimonials and independent website reviews. For the mid-to-higher end of the market, £30 to £200 products, it's unusual not to have some clinical test data to validate the products worth.

How long has the product been on the market?

There are some products that have been around for years and they are just too good and efficient to remove from the market. The main cost for a new product is the years of research and development, in particular the successful arrangement of the formula ingredients and most importantly the results gained from testing the finished formulation. New products on the market are always exciting because we all like to believe the miracle is in the next jar we buy. This said there are many products that are not promising anything new but are just re-marketed under new branding. A new product that no one knows is always a gamble, search for reviews, evidence (clinical studies) and check the pedigree of the manufacturer.

What is the retail price of the product?

Well for many the most important factor is value for money (cost Vs. results). If a sample size product is available, this has to be the best way to test the products quality when applied to the skin, which is often the biggest issue when purchasing products at the lower end of the market.

Consider the on-going cost to use the product, the real cost of the product, and how likely the product will be discounted in future and to what degree the product might be discounted.

Sometimes we just have to pay the asking price to gain products that just perform really well and meet the expectations we desire. This said there are a few things to consider when paying the asking price including; "How much did the product cost to make and how much has it been inflated and most importantly why?"

Typically a good quality skincare product will cost the manufacturer around £5 and the distributor may pay around £8 and the retailer may pay around £14 and the consumer around £30. There are many people in the chain which is the reason for the retail price of this product. If there are no comparable products within the market then our options are really limited. The longer a product has been on the market, there is normally more competition, so over time the price of the product to the consumer is decreased through discounts and multi-buy promotions.

Large supermarket chains who generally buy products from the manufacturer directly are best placed to deliver products at the lower end as there is no middle man to profit. This said, a normal skincare product supplied by supermarkets are sold with a 70% to 90% profit margin, hence there are always promotions in supermarkets.

Manufacturers who sell their products directly to consumers are these days almost impossible to find. There are however more and more country distributors deciding to cut out the middle man (pharmacy, high street retailer, SPA, clinics) and supply the products directly via the internet. Again you will find the product at retail price but you will also notice there will be many instances whereby the distributor is able to provide very high discounts off their products and other exciting promotions.



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